evaluation of antifungal effect of silver nanoparticles against microsporum canis, trichophyton mentagrophytes and microsporum gypseum

background : dermatophytosis is the common cutaneous infections in humans and animals, which is caused by the keratinophylic fungus called dermatophytes. in recent years , drug-resistance in pathogenic fungi, including dermatophytes to the current antifungal have been increased . the aim of this study was to evaluate the antifungal efficacy of agnps against microsporum canis, trichophyton mentagrophytes, and microsporum gypseum.materials and methods: the antifungal susceptibility of nano-silver particles (agnps) compared with griseofulvin (gr). its efficacy was investigated against three strains of dermatophytes by both agar dilution and broth microdilution test (bmd).results : the average minimum inhibitory concentration (mic) of ag-nps on m. canis, t. mentagrophytes and m. gypseum were 200, 180, and 170 μg/ml , respectively. whereas these strains showed mic of 25, 100 and 50 μg/ml for griseofulvin (gr). conclusions: our finding indicated that the agnps was less active than griseofulvin (gr) but it had anti-dermatophytic effect.